Citation: Zhen-Xing Zou, Kang-Ping Xu, Fu-Shuang Li, Hui Zou, Min-Zhen Liu, Qiong Zhang, Kai Yu, Lan-Fang Zhao, Lei-Hong Tan, Gui-Shan Tan. A new pyrrole alkaloid from Selaginella moellendorfii Hieron[J]. Chinese Chemical Letters, ;2013, 24(2): 114-116. shu

A new pyrrole alkaloid from Selaginella moellendorfii Hieron

1.
a School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;
2.
b Xiangya Hospital of Central South University, Changsha 410008, China

Corresponding author: Gui-Shan Tan,
Received Date: 9 November 2012
Available Online: 5 January 2013
Fund Project: This research was supported by the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057) (No. 20100162110057) National Natural Science Foundation (No. 30873149) (No. 30873149) Fundamental Research Funds for the Central South Universities of Central South University (No. 2012zzts115) (No. LA10031) and Independent Exploration Program of Central South University (No. 201011200235). (No. 2012zzts115)

One new pyrrole alkaloid, N-(2E)-3-(3,4-dihydrophenyl)prop-N_1'-(4-aminobutyl)-3-pyrrole formaldehyde (1), was isolated from the whole herbs of Selaginella moellendorfii Hieron. The structure was elucidated by spectroscopic analyses including UV, IR, 1D NMR, 2D NMR and MS methods. Additionally, compound 1 exhibited potent protective effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro.
- Selaginella,
- Selaginella moellendorfii Hieron,
- Pyrrole alkaloid,
- HUVECs
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