Citation: Shrong Shi LIN, Jun Hua YU, Jian Mei WANG, Bo YANG, Xiu Lin YE. The Synthesis of 4-Arylcarbonyl-3-methoxycarbonyl-2-phenylfurans by Friedel-Crafts Acylation Reactions[J]. Chinese Chemical Letters, ;2000, 11(1): 11-14. shu

The Synthesis of 4-Arylcarbonyl-3-methoxycarbonyl-2-phenylfurans by Friedel-Crafts Acylation Reactions

Department of Chemistry, Peking University, Beijing 100871

Received Date: 9 August 1999

Keto esters 8, 4-arylcarbonyl-3-methoxycarbonyl-2-phenylfurans, potential precursors of the synthesis of furofuran lignans, were obtained from dimethyl 2-phenylfuran-3, 4-dicarboxylate 2. Diester 2 was selectively hydrolyzed to monoacid 6 followed by converting to its acid chloride 7. Friedel-Crafts acylation reactions of 7 with aromatic compounds afforded keto esters 8. The geometric structures of 8 and its precursors were elucidated and verified by NMR spectra.
- Friedel-Crafts acylation,
- selective mono hydrolysis,
- furofuran lignan
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