Citation: Guo Qiang HU, Sheng LI, Wen Long HUANG. Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits[J]. Chinese Chemical Letters, ;2006, 17(7): 899-902. shu

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits

1.
Institute of Pharmacy, Henan Unversity, Kaifeng 475001;
2.
China Pharmaceutical University, Nanjing 210009

Received Date: 11 January 2006

Fund Project: This project was supported by the State Basic Research and Development Project (No. G 1998051112) and the Science Foundation of Henan University (04ZDZR009).

4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1-phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1-one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-chloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e),respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G⁺) and Gram negative (G^-)bacteria was primarily evaluated.
- Pyridine,
- triazole,
- oxadiazole,
- oxime-ether,
- schiff base,
- antibacterial activity
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