Citation: Jian Ya LING, Qin Zheng YANG, Shan Shan LUO, Yan LI, Chang Kai ZHANG. Preliminary Study on Cordycepin-DNA Interaction by Raman Spectroscopy[J]. Chinese Chemical Letters, ;2005, 16(1): 71-74. shu

Preliminary Study on Cordycepin-DNA Interaction by Raman Spectroscopy

State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100

Received Date: 3 December 2003

Fund Project: Project 3037014 was supported by the National Natural Science Foundation of China.

The interaction of cordycepin with calf thymus DNA was investigated at physiological pH with drug/DNA molar ratio of 8. The Raman spectroscopy results indicated that the intercalation of high concentration cordycepin and the interaction of cordycepin with PO₂ group led to a major reduction of B-form DNA structure in favor of A-form DNA.
- Cordycepin,
- calf thymus DNA,
- Raman spectroscopy,
- conformation.
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