Citation: . SOLUTION PROPERTIES OF ANTITUMOR CARBOXYMETHYLATED DERIVATIVES OF α-(1→3)-D-GLUCAN FROM GANODERMA LUCIDUM*[J]. Chinese Journal of Polymer Science, ;2001, 19(3): 283-289. shu

SOLUTION PROPERTIES OF ANTITUMOR CARBOXYMETHYLATED DERIVATIVES OF α-(1→3)-D-GLUCAN FROM GANODERMA LUCIDUM*

Received Date: 26 June 2000

Fractions of a water insoluble α-(1→3)-D-glucan (GL) extracted from Ganoderma lucidum were carboxy-methylated (CM) to obtain water-soluble carboxymethylated derivatives (CM-GL) having a degree of substitution (DS) of 0.38～0.51. Weight-average molecular weight Mw and intrinsic viscosity [η] of the samples CM-GL were measured by gelpermeation chromatography combined with laser light scattering (GPC-LLS) and viscometry. The CM-GL exhibits a stifferchain in aqueous solution at 25℃ than the original glucan. The antitumor activities against Ehrlich ascites carcinoma(EAC,5×106) of the carboxymethylated derivatives from the α-glucan and curdlan,a β-glucan,are significantly higher than those of the original glucans.The effects of the relatively low molecular weight,expanded chains and better water-solubility of the CMM-GL on the enhancement of antitumor activity could not be neglected.The chain stiffness decreased speedily with increase of temperature from 40 to 60℃ or NaOH concentration from 0.1 to 0.4 in the solution,respectively,and the change of the chain stiffness is reversible.
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