Citation: Fend Peng WANG, Ju Zheng FAN, Zheng Bang LI, Jin Song YANG, Bo Gang LI. Modifications of Norditerpenoid Alkaloids:Ⅰ.N-Deethylation Reactions[J]. Chinese Chemical Letters, ;1999, 10(5): 375-378. shu

Modifications of Norditerpenoid Alkaloids:Ⅰ.N-Deethylation Reactions

1.
Department of Chemistry of Medicinal Natural Products, School of Pharmacy, West of China University of Medical Sciences, Chengdu 610041;
2.
Chengdu Institute of Biologe, Chinese Academy of Sciences, Chengdu 610041

Received Date: 23 November 1998

Fund Project: We thank the National Natural Science Foundation of China (No.39370807) and the Chengdu Diao Pharmaceutical Company for support of this work. We also thank Professor Xiao Tian LIANG for helpful discussion on the subject.

Usine oxidation with KMnO₄. KMnO₄/acetonc-H₂O, NBS. followed by Polonovsky reaction and imine formation. the N-deethylatiun of sit norditerpenoid alkaloids 6-epi-forsticine yunnaconitine, 3,13-diacetylyunnacunitine, 13-dehydry-indacunitine, indacunitinc and acetylpseudaconine are reported in 36-60% yields.
- Norditerpenpid alkaloids,
- N-deethy lation
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