Citation: Li Gang ZHANG, Ji Mei MIN, Li He ZHANG. Synthesis of Two New Chiral Blocks for the Construction of Peptide Nucleic Acid (PNA)[J]. Chinese Chemical Letters, ;1999, 10(3): 195-198. shu

Synthesis of Two New Chiral Blocks for the Construction of Peptide Nucleic Acid (PNA)

National Laboratory of Natural and Biomimetic Drugs, Bet-ling Medical University, Beijing 100083

Received Date: 11 September 1998

Fund Project: We thank the National Natural Science Foundation of China for the financial support.

Protected (I.) and (D)-lysune wore used respectively as starting materials to synthesize two new types of chiral blocks for the construction of PNA.Nucleobasc was linked to α-NH₂ of lysine via -CH₂C (O)- spacer in type 1.and -C (O)- was used in type Ⅱ.The corresponding oligomers were constructed in solution.
- Peptide nucleic acid (PNA),
- lysine,
- synthcsis
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