Citation: Xue Gong SHE, Wen Xin GU, Hua WANG, Xin Fu PAN. Stereoselective Synthesis of 2-(4-Hydroxyphenyl)-3-hydroxymethyl-1,4-benzodioxane-6-aldehyde-The Key Intermediate of Sinaiticin[J]. Chinese Chemical Letters, ;1999, 10(2): 107-108. shu

Stereoselective Synthesis of 2-(4-Hydroxyphenyl)-3-hydroxymethyl-1,4-benzodioxane-6-aldehyde-The Key Intermediate of Sinaiticin

Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000

Received Date: 23 July 1998

Fund Project: We are grateful to the National Natural Science Foundation of China for financial support.

2-(4-Hydroxyphenyl)-3-hydroxymethyl-l,4-benzodioxane-6-aldehyde 8, the key intermediate of sinaiticin 10. was synthesized in 6 steps from caffeic acid 4 and 4-hydroxybenzaldehyde 1, the coupling reaction is the key step.
- 2-(4-Hydroxyphenyl)-3-hydroxymethyl-1,
- 4-benzodioxane-6-aldehyde,
- key intermediate,
- sinaiticin,
- synthesis
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