Citation: Xiao Bai XU, Surinder KAUR, David MALTBY, Alma BURLINGAME. XENOBIOTICALLY MODIFIED HUMAN HEMOGLOBIN STUDIED BY ELECTROSPRAY MASS SPECTROMETRY[J]. Chinese Chemical Letters, ;1995, 6(5): 399-402. shu

XENOBIOTICALLY MODIFIED HUMAN HEMOGLOBIN STUDIED BY ELECTROSPRAY MASS SPECTROMETRY

a Research Center for Eco-environmental Sciences, Academia Sinica, Beijing, 100085;
b Mass Spectrometry Facility Laboratory, Department of Pharmaceutical Chemistry, UC San Francisco CA 94143, USA

Received Date: 5 December 1994

Fund Project: This work was supported by NIEHS grant ES04705,NIH grant RR01614 and NSF grant DIR 8700766.We gratefully acknowledge the help of F.C.Walls in the Mass Spectrometry Facility and Dr.R.Des Jarlais in the computer graphics laboratory (grant RR0181). XBX would also like to thank Dr. A.Falick, Dr.K.W.Wang, and Dr.K.Jiang for their advices, Ms. T. Qin for preparing manuscript, and partial support from NSFC.

High performance liquid chromatography (HPLC)/electrospray mass spectrometry (ES MS) has been used to measure successfully the molecular weights of intact α and β chains of globin covaleutly modified with styrene oxide,having the molecular weight of xenobiotic moiety as 120 Da.The method also has revealed a variety of modified residues in the reacted hemoglobin after digestion with trypsin.
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