Citation: Yun Long LI, Xu Chang HE, Dong Lu BAI. SYNTHESIS OF ANALOGUES OF HUPERZINE A 4.THE PREPARATION OF A PYRIMIDONE ANALOGUE OF HUPERZINE A[J]. Chinese Chemical Letters, ;1996, 7(2): 111-114. shu

SYNTHESIS OF ANALOGUES OF HUPERZINE A 4.THE PREPARATION OF A PYRIMIDONE ANALOGUE OF HUPERZINE A

Shanghai Institute of Materia Medica, Chinese Academy of Sciences 294 Tai-Yuan Road, Shanghai, 200031

Received Date: 23 June 1995

Fund Project: This work was financially supported by a grant of the National Natural Science Foundation of China.

The preparation of a pyrimidone analogue 2 of huperzine A is described,in which the pyridone ring of the natural alkaloid is replaced by pyrimidone.The key intermediate β-ketoester 9 was obtained from cyclohexane-1,4-dione monoethylene ketal via 6 steps.Then using the methodology of total synthesis of huperzine A,the construction of bicyclo[3.3.1]nonane moiety substructure was achieved,and 2 was finally afforded in low yield.
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