Citation: Xi Cun WANG, Jun Ke WANG, Zheng LI. Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di (aryloxyacetyl) thiosemicarbazides[J]. Chinese Chemical Letters, ;2004, 15(6): 635-638. shu

Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di (aryloxyacetyl) thiosemicarbazides

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received Date: 26 May 2003

Fund Project: The authors thank the Scientific and Technological Innovation Engineering of Northwest Normal University (NWNU-KJCXGC-02-08), Natural Science Foundation of Gansu Province (ZS021-A25-006-Z), Environmental Protection Foundation of Gansu Province (GH2002-16) for the financial support of this work.

An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemi-carbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4'-methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity.
- Liquid-phase synthesis,
- PEG,
- di(aryloxyacetyl)thiosemicarbazide
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