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Citation: WANG Huiyan, ZHOU Dandan, CHEN Zijun. Synthesis of 4-Hydroxy-3-(2-imino ethyl)-2H-chromen-2-one Derivatives under Ultrasound Irradiation[J]. Chinese Journal of Applied Chemistry, ;2013, 30(2): 153-158. doi: DOI:10.3724/SP.J.1095.2013.20129 shu

Synthesis of 4-Hydroxy-3-(2-imino ethyl)-2H-chromen-2-one Derivatives under Ultrasound Irradiation

1.
a Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China;
2.
b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Corresponding author: WANG Huiyan,
Received Date: 1 April 2012
Available Online: 11 July 2012
Fund Project: 江苏省普通高校研究生科研创新计划资助项目(CXZZ11_0090) (CXZZ11_0090)

A series of 4-hydroxy-3-(2-imino ethyl)-2H-chromen-2-ones was first synthesized by the reaction of 4-hydroxy-3-acetyl coumarin and amines in alcohol with 4-methylbenzenesulfonic acid as catalyst under ultrasonic irradiation.The yields were in the range of 62%~94%.The structures of the products were confirmed by IR,¹H NMR and HRMS.The structure of compound 3c was determined by X-ray single-crystal diffractions.The advantages of this method are high yield,shorter reaction time,mild condition and simple work-up procedures.
- Schiff base,
- acetyl-hydroxy-2H-chromen-one,
- ultrasound irradiation,
- synthesis
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