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Citation: Yu Fei, Zheng Yongxiang, Peng Yiyun, Zhou Demin, Xiao Sulong. Design and Synthesis of Oleanolic Acid Rings A and C Lactone Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(3): 512-519. doi: 10.6023/cjoc204509001 shu

Design and Synthesis of Oleanolic Acid Rings A and C Lactone Derivatives

Yu Fei ^a,, ,
Zheng Yongxiang ^b ,
Peng Yiyun ^b ,
Zhou Demin ^b ,
Xiao Sulong ^b,,

1.
a Medical Faculty, Kunming University of Science and Technology, Kunming 650500;
2.
b State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191

Corresponding author: Yu Fei, Xiao Sulong,
Received Date: 1 September 2015
Available Online: 27 November 2015
Fund Project: 天然药物及仿生药物国家重点实验室开放基金(No. K20150214) (No. K20150214)昆明理工大学人才引进(No. KKSY201560002)资助项目. (No. KKSY201560002)

Oleanolic acid (OA), a naturally occurring triterpene, was found to have a variety of biological and pharmacological properties. To expand its structural diversity, a series of oleanolic acid derivatives, including ring A and/or ring C expansion, were performed via Baeyer-Villiger reaction using m-CPBA and urea-hydrogen peroxide. The structures of all products were characterized by ¹H NMR, ¹³C NMR and HRMS.
- oleanolic acid,
- Baeyer-Villiger reaction,
- lactone
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