Citation: Zheng Dandan, Ni Yadan, Qian Cheng, Zhang Min, Zhang Zichan, Dai Hong, Zhou Beibei, Zhang Lifang. Synthesis and Biological Activities of Novel N-Pyridylpyrazole Amide Compounds Carrying Isoxazole Unit[J]. Chinese Journal of Organic Chemistry, ;2020, 40(12): 4249-4257. doi: 10.6023/cjoc202008014 shu

Synthesis and Biological Activities of Novel N-Pyridylpyrazole Amide Compounds Carrying Isoxazole Unit

College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019

Corresponding author: Dai Hong, daihong_2015@aliyun.com Zhang Lifang, lfzhang@ntu.edu.cn
Received Date: 10 August 2020
Revised Date: 1 September 2020
Available Online: 8 September 2020
Fund Project: the National Natural Science Foundation of China 21372135Project supported by the National Natural Science Foundation of China (No. 21372135) and the Science and Technology Project Fund of Nantong City (No. MS12019060)the Science and Technology Project Fund of Nantong City MS12019060

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A series of new N-pyridylpyrazole amides bearing substituted isoxazole moiety were designed and prepared based on chlorantraniliprole. These compounds were structurally determined through ¹H NMR, ¹³C NMR and elemental analyses. Bioassay results displayed that all designed compounds showed a mortality rate of 100% towards Oriental armyworm at the dosage of 500 μg/mL. At the dosage of 100 μg/mL, the mortality rates of four compounds towards Oriental armyworm were 80%~100%. Two compounds had 40%~50% insecticidal activities towards Oriental armyworm at the concentration of 20 μg/mL. At the concentration of 500 μg/mL, five compounds demonstrated 90%~100% insecticidal activities against Aphis medicaginis. Moreover, at the dosage of 500 μg/mL, two compounds exhibited 70%~80% insecticidal activities against Tetranychus cinnabarinus.
- isoxazole,
- N-pyridylpyrazole,
- synthesis,
- biological activity
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