Citation: Jiang Guofang, Lu Yue, Li Hongxia, Hu Zhiyu, Zhu Xiao, Xie Zongbo, Le Zhanggao. New Use of Non-natural Catalytic Activity of Pepsin: Highly Efficient Synthesis of Tetrahydroquinazolines[J]. Chinese Journal of Organic Chemistry, ;2020, 40(9): 2827-2835. doi: 10.6023/cjoc202006006 shu

New Use of Non-natural Catalytic Activity of Pepsin: Highly Efficient Synthesis of Tetrahydroquinazolines

Jiangxi Province Key Laboratory of Synthetic Chemistry, School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang, Jiangxi 330013

Corresponding author: Xie Zongbo, zbxie@ecut.edu.cn Le Zhanggao, zhgLe@ecut.edu.cn
Received Date: 5 June 2020
Revised Date: 12 June 2020
Available Online: 24 June 2020
Fund Project: the National Natural Science Foundation of China 21462001Project supported by the National Natural Science Foundation of China (No. 21462001), and the Science and Technology Projects of Jiangxi Province (No. 20161BCB24006)the Science and Technology Projects of Jiangxi Province 20161BCB24006

Figures(3)

Pepsin from porcine gastric mucosa has a non-natural ability to catalyze the cyclocondensation of aromatic amines and 2-aminobenzaldehyde. The corresponding tetrahydroquinazolines were obtained in good yields (41%~95%) in aqueous methanol solution. The catalytic activity of pepsin was evaluated by investigating solvent, temperature, enzyme loading, and substrate ratio in the enzyme-catalyzed reaction. Herein, a potential biocatalytic approach as an alternative to chemical synthesis for tetrahydroquinazoline derivatives was proposed.
- pepsin,
- non-natural catalytic activity,
- tetrahydroquinazoline,
- biocatalysis
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