Citation: Lin Ye, Du Daming. Recent Advances in Squaramide-Catalyzed Asymmetric Cascade Reactions for the Synthesis of Spirooxindoles[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3214-3236. doi: 10.6023/cjoc202005065 shu

Recent Advances in Squaramide-Catalyzed Asymmetric Cascade Reactions for the Synthesis of Spirooxindoles

Lin Ye ,
Du Daming ^,

School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081

Corresponding author: Du Daming, dudm@bit.edu.cn
Received Date: 23 May 2020
Revised Date: 13 June 2020
Available Online: 19 June 2020

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Chiral spirooxindoles have captured huge attention from researchers in the area of organic chemistry and medicinal chemistry owing to their prevalence in various alkaloid natural products and pharmacologically active agents. In recent year, chiral bifunctional squaramide-catalyzed asymmetric cascade reaction of oxindoles or oxindole derivatives has become an efficient synthetic method for the construction of chiral spirooxindoes. In this review, the remarkable progress and advances in bifunctional squaramide-catalyzed asymmetric cascade reactions for the synthesis of spirooxindole derivatives from 2015 are summarized and discussed based on the different types of catalytic reactions.
- spirooxindoles,
- asymmetric organocatalysis,
- squaramides,
- cascade reactions
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