Citation: Sun Zezhong, Xu Miao, Wang Yunxia, Hu Xiangdong. Synthetic Progress of Alkaloids against Mycobacterium Tuberculosis: Pseudopteroxazole and Ileabethoxazole[J]. Chinese Journal of Organic Chemistry, ;2020, 40(12): 4203-4215. doi: 10.6023/cjoc202005034 shu

Synthetic Progress of Alkaloids against Mycobacterium Tuberculosis: Pseudopteroxazole and Ileabethoxazole

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710127

Corresponding author: Wang Yunxia, wyx27210@nwu.edu.cn Hu Xiangdong, xiangdonghu@nwu.edu.cn
Received Date: 14 May 2020
Revised Date: 11 June 2020
Available Online: 24 June 2020
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21772153), the Science and Technology Department of Shaanxi Province (No. S2019-JC-YB-0846) and the Key Science and Technology Innovation Team of Shaanxi Province (No. 2017KCT-37)the National Natural Science Foundation of China 21772153the Science and Technology Department of Shaanxi Province S2019-JC-YB-0846the Key Science and Technology Innovation Team of Shaanxi Province 2017KCT-37

Figures(11)

Two alkaloids of pseudopteroxazole and ileabethoxazole, isolated from sea whip Pseudopterogorgia elisabethae, have significant antimicrobial activity against pathogen of tuberculosis:Mycobacterium tuberculosis. These two alkaloids possess similar tetracyclic skeleton, which containing four stereocenters, a fully substituted aromatic ring and an uncommon benzoxazole unit in natural products. Significant antimicrobial activity and special molecular structures attracted extensive attentions to synthetic study on pseudopteroxazole and ileabethoxazole. The progress in the total synthesis of these two alkaloids is reviewed.
- Mycobacterium tuberculosis,
- alkaloid,
- pseudopteroxazole,
- ileabethoxazole,
- total synthesis
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