Citation: Li Yi, Wan Jieping. Synthesis of 3-Alkylthiol Pyrazoles via Regioselective Annulation Reactions of Sulfonyl Hydrazines and Ketene Dithioacetals[J]. Chinese Journal of Organic Chemistry, ;2020, 40(11): 3889-3894. doi: 10.6023/cjoc202005026 shu

Synthesis of 3-Alkylthiol Pyrazoles via Regioselective Annulation Reactions of Sulfonyl Hydrazines and Ketene Dithioacetals

  • Corresponding author: Wan Jieping, wanjieping@jxnu.edu.cn
  • Received Date: 10 May 2020
    Revised Date: 16 June 2020
    Available Online: 15 July 2020

    Fund Project: Project supported by the National Natural Science Foundation of China (No. 21861019)the National Natural Science Foundation of China 21861019

Figures(3)

  • By using sulfonyl hydrazines and ketene dithioacetals as starting materials, the regioselective annulation providing 3-alkylthiolated pyrazoles has been realized in the low cost and easily available NaHSO4 catalytst. The reactions were realized in 1, 4-dioxane medium and 80 ℃ heating, whereby a seris of 3-alkylthiol pyrazoles possessing N-sulfonyl structure have been efficiently synthesized.
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