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Citation: Pan Chao, Liu Peng, Wu An'guo, Li Ming, Wen Lirong, Guo Weisi. Electrochemical-Promoted Synthesis of 2-Thiazolines via Selenylation/Cyclization of N-Allylthioamides[J]. Chinese Journal of Organic Chemistry, ;2020, 40(9): 2855-2862. doi: 10.6023/cjoc202004051 shu

Electrochemical-Promoted Synthesis of 2-Thiazolines via Selenylation/Cyclization of N-Allylthioamides

State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042

Corresponding author: Wen Lirong, wenlirong@qust.edu.cn Guo Weisi, wsguo@qust.edu.cn
Received Date: 30 April 2020
Revised Date: 7 June 2020
Available Online: 19 June 2020
Fund Project: the Natural Science Foundation of Shandong Province ZR2019MB010the National College Student's Innovation and Entrepreneurship Training Program 201910426037the National Natural Science Foundation of China 21572110Project supported by the National Natural Science Foundation of China (No. 21572110), the Natural Science Foundation of Shandong Province (No. ZR2019MB010) and the National College Student's Innovation and Entrepreneurship Training Program (No. 201910426037)

Figures(3)

An electrochemical selenylation/cyclization of N-allylthioamides has been developed for the synthesis of selenium-containing 2-thiazolines. This protocol provides an efficient approach to produce 2-thiazolines with broad substrate scope under mild reaction conditions. Preliminary mechanistic study indicates that selenium radical may be involved. The reaction is easy operated under catalyst- and oxidant-free conditions.
- electrosynthesis,
- thiazolines,
- thioamides,
- selenation
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