Citation: Lin Cong, Gao Zhenbo, Teng Qiuxun, Xue Bowen, Li Xiaohua, Gao Fei, Shen Liang. Synthesis of Vinyl-Substituted Dihydroisoquinolone via Ru(Ⅱ)-Catalyzed C—H Functionalization/Annulation of Imidates[J]. Chinese Journal of Organic Chemistry, ;2020, 40(9): 2863-2870. doi: 10.6023/cjoc202004048 shu

Synthesis of Vinyl-Substituted Dihydroisoquinolone via Ru(Ⅱ)-Catalyzed C—H Functionalization/Annulation of Imidates

College of Chemistry and Chemical Engineering, Jiangxi Science & Technology Normal University, Nanchang 330013

Corresponding author: Lin Cong, conglin0127@jxstnu.com.cn Shen Liang, liangshen@jxstnu.com.cn
Received Date: 29 April 2020
Revised Date: 4 June 2020
Available Online: 19 June 2020
Fund Project: the Natural Science Foundation of Jiangxi Province 20202BABL213005the National Natural Science Foundation of China 21704036Project supported by the National Natural Science Foundation of China (Nos. 51963010, 21704036) and the Natural Science Foundation of Jiangxi Province (No. 20202BABL213005)the National Natural Science Foundation of China 51963010

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An efficient and powerful approach for the construction of vinyl-substituted dihydroisoquinolone derivatives through ruthenium-catalyzed tandem C—H functionalization/annulation of imidates has been demonstrated. Various substituted functional groups of imidates could be well tolerated in this new transformation, delivering the corresponding products in moderate to good yields. This method represents the first successful example of Ru(Ⅱ)-catalyzed C—H functionalization/an-nulation of imidates with 4-vinyl-1, 3-dioxolan-2-one to the efficient synthesis of 3-vinyl-3, 4-dihydroisoquinolin-1(2H)-ones.
- vinyl-substituted dihydroisoquinolone,
- ruthenium-catalysis,
- C-H functionalization,
- imidate,
- 4-vinyl-1, 3-di-oxolan-2-one
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