Citation: Wang Hui, Wang Anwei, Xia Zhenzhen, Zhou Weiyou, Sun Zhonghua, Qian Junfeng, He Mingyang. Nickel(Ⅱ)-Catalyzed Aerobic Cross-Dehydrogenative Coupling for the Synthesis of N-Aryl Tetrahydroisoquinolines[J]. Chinese Journal of Organic Chemistry, ;2020, 40(7): 2099-2107. doi: 10.6023/cjoc202004028 shu

Nickel(Ⅱ)-Catalyzed Aerobic Cross-Dehydrogenative Coupling for the Synthesis of N-Aryl Tetrahydroisoquinolines

Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164

Corresponding author: Zhou Weiyou, zhouwy426@126.com
Received Date: 18 April 2020
Revised Date: 4 May 2020
Available Online: 15 May 2020
Fund Project: the Natural Science Foundation of Jiangsu Province No. BK20181461the Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology No. BM2012110the Postgraduate Research & Practice Innovation Program of Jiangsu Province No. KYCX19_1746Project supported by the Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology (No. BM2012110), the Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. KYCX19_1746), and the Natural Science Foundation of Jiangsu Province (No. BK20181461)

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An nickel-catalyzed aerobic cross-dehydrogenative coupling of N-aryl tetrahydroisoquinolines is presented. The catalytic system could tolerate various N-aryl tetrahydroquinoline derivatives and nucleophiles, and the target products could be obtained in good to excellent yields. Compared with reported methods, the protocol uses molecular oxygen as a sustainable oxidant, and provides an effective approach to the synthesis of tetrahydroisoquinoline derivatives under mild and practical conditions.
- cross-dehydrogenative coupling,
- C—H activation,
- nickel,
- molecular oxygen,
- N-aryl tetrahydroisoquinoline
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