Citation: Zeng Hongyun, Zhang Jun'gan, Hong Wei. New Method for the Synthesis of 2, 5-Diaryl Substituted Thiazoles[J]. Chinese Journal of Organic Chemistry, ;2020, 40(8): 2535-2542. doi: 10.6023/cjoc202004020 shu

New Method for the Synthesis of 2, 5-Diaryl Substituted Thiazoles

a.
School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021
b.
Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021

Corresponding author: Hong Wei, hongwei@nmu.edu.cn
Received Date: 13 April 2020
Revised Date: 22 May 2020
Available Online: 29 May 2020
Fund Project: the National Natural Science Foundation of China 81960623Project supported by the National Natural Science Foundation of China (Nos. 81660588, 81960623) and the National Ethnic Affairs Commission Young Talent Training Programthe National Natural Science Foundation of China 81660588

Figures(3)

Thiazole ring is an important five-membered aromatic heterocyclic ring, and its derivatives have various biological activities and are widely used in medicine. The synthesis of 2, 5-diarylthiazole derivatives by acylation, thiolation, cyclization and Heck reaction using inexpensive and readily available substituted benzoic acid as raw materials was developed. The key point was to optimize the Heck reaction conditions and explore the possible reaction mechanism. The method has mild reaction conditions, simple operation, and good substrate universality, which provides a new direction for the synthesis of 2, 5-diaryl substituted thiazoles.
- 2, 5-diarylthiazole,
- Heck reaction,
- organic synthesis
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