Citation: Tian Xueqi, Zuo Minzan, Niu Pengbo, Wang Kaiya, Hu Xiaoyu. Research Advances of Host-Guest Supramolecular Self-Assemblies with Aggregration-Induced Emission Effect and Their Applications in Biomedical Field[J]. Chinese Journal of Organic Chemistry, ;2020, 40(7): 1823-1834. doi: 10.6023/cjoc202003066 shu

Research Advances of Host-Guest Supramolecular Self-Assemblies with Aggregration-Induced Emission Effect and Their Applications in Biomedical Field

College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106

Corresponding author: Hu Xiaoyu, huxy@nuaa.edu.cn
Received Date: 30 March 2020
Revised Date: 21 April 2020
Available Online: 7 May 2020
Fund Project: The Fundamental Research Funds for the Central Universities NE2019002Project supported by the Natural Science Foundation of Jiangsu Province BK20180055The China Postdoctoral Science Foundation Project 2019M661816Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20180055), the Fundamental Research Funds for the Central Universities (No. NE2019002) and the China Postdoctoral Science Foundation Project (No. 2019M661816)

Figures(19)

Host-guest interaction, as one of the most important behaviors in supramolecular self-assemblies, is often used to construct functional supramolecular materials. Based on host-guest interaction, it has become a hotspot in supramolecular chemistry by utilizing macrocyclic hosts and guests with aggregation-induced emission (AIE) properties as building blocks to construct supramolecular system, which can be widely used in drug delivery, cellular imaging, biosensing and so on. According to the origination of fluorescence effects of supramolecular assemblies, either from the host or guest molecules, the recent 5-year advances of AIE supramolecular self-assemblies based on host-guest interaction by utilizing macrocycles such as cyclodextrin, calixarene, cucurbituril, pillararene and other water-soluble host molecules are summarized, and their applications in the biomedical field are discussed.
- host-guest interaction,
- self-assembly,
- aggregation-induced emission,
- cell imaging,
- drug delivery
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