Chlorosulfonation of Acetanilide in a Dual-Temperature-Zone Silicon Carbide Microchannel Reactor and Synthesis of Sulfasalazine
- Corresponding author: Geng Huiling, genghuiling@nwsuaf.edu.cn
Citation:
Zhang Zishu, Zhao Yulong, Geng Huiling. Chlorosulfonation of Acetanilide in a Dual-Temperature-Zone Silicon Carbide Microchannel Reactor and Synthesis of Sulfasalazine[J]. Chinese Journal of Organic Chemistry,
;2020, 40(8): 2387-2393.
doi:
10.6023/cjoc202003053
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Reagents and conditions: (a) 2-aminopyridine, Et3N, 30~35 ℃; (b) NaOH, MeOH, r.t.~75 ℃; (c) (i) HCl, NaNO2, (ii) NH2CONH2, NaO-H in a microchannel reactor; (d) (i) NaOH, salicylic acid, (ii) HCl