Citation: Chen Ying, Jing Xiaobi, Yu Lei. Polyaniline-Supported Copper-Catalyzed Buchwald-Hartwig Couplings of Pyrimidin-2-amines[J]. Chinese Journal of Organic Chemistry, ;2020, 40(8): 2570-2574. doi: 10.6023/cjoc202003044 shu

Polyaniline-Supported Copper-Catalyzed Buchwald-Hartwig Couplings of Pyrimidin-2-amines

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002

Corresponding author: Jing Xiaobi, xbjing@yzu.edu.cn Yu Lei, yulei@yzu.edu.cn
Received Date: 17 March 2020
Revised Date: 1 May 2020
Available Online: 19 May 2020
Fund Project: the Natural Science Foundation of Jiangsu Province BK20181449the Jiangsu Provincial Six Talent Peaks Project XCL-090Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20181449), the Jiangsu Provincial Six Talent Peaks Project (No. XCL-090) and the Priority Academic Program Development of Jiangsu Higher Education Institutions

Figures(2)

Buchwald-Hartwig couplings can modify the pyrimidin-2-amines. Since the pyrimidin-2-amine structures widely exist in medicines, the reaction is of significant industrial application values. The polyaniline-supported copper catalyst (Cu@PANI) was synthesized via the oxidative polymerization of aniline in the presence of copper salt and it could catalyze the Buchwald-Hartwig couplings of pyrimidin-2-amines. Since the nitrogen in polyaniline could well coordinate with copper, the reaction did not require additional ligands and occurred at relatively high catalyst turnover numbers (TONs). As a heterogeneous catalyst, Cu@PANI could be recycled and reused to reduce the cost of catalyst, and meet the requirements of industrial application.
- polyaniline,
- copper,
- catalysis,
- Buchwald-Hartwig coupling,
- ligand-free
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