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Citation: Liu Guiyuan, Guo Dale, Deng Yun, Linghu Lang, Zhang Maosheng, He Yuqi, Xiao Shiji. Lignans from the Heartwood of Nothotsuga longibracteata[J]. Chinese Journal of Organic Chemistry, ;2020, 40(7): 2120-2126. doi: 10.6023/cjoc202003021 shu

Lignans from the Heartwood of Nothotsuga longibracteata

  • a.

    School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563006

  • b.

    School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137

  • Corresponding author: Xiao Shiji, sjxiao@zmu.edu.cn
  • Received Date: 8 March 2020
    Revised Date: 23 April 2020
    Available Online: 7 May 2020

    Fund Project: the National Natural Science Foundation of China 31560102Project supported by the National Natural Science Foundation of China (No. 31560102)

Figures(4)

  • 3-(4'-Hydroxy-3'-methoxybenzyl)-2(5H)-furanone (1), a rare benzyl furanone derivate, and two new lignans (2 and 3) were isolated from the heartwood of Nothotsuga longibracteata, together with nineteen known lignans compounds. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESI-MS, 1D NMR, 2D NMR, and CD spectroscopies. The cytotoxic effects of the isolated new lignan compounds on three human tumour cell lines (A172, SHSY5Y, and Hela) were evaluated by methyl thiazolyl tetrazolium (MTT) assay. Their showed no cytotoxic activities at the concentration of 50 μmol/L. Gastrointestinal motility test of zebrafish showed that compound 3 has the function of promoting gastrointestinal motility of zebrafish to excrete Nile red at doses 8 and 24 μmol/L by means of acting on the cholinergic nervous system.
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