Citation: Yang Min, Xia Lili, Zhou Xiaoqin, Jia Chengli, Ji Min, Wang Peng. A Ratiometric Fluorescent Probe for Imaging Hydrogen Peroxide in Living Cells[J]. Chinese Journal of Organic Chemistry, ;2020, 40(9): 2888-2894. doi: 10.6023/cjoc202002030 shu

A Ratiometric Fluorescent Probe for Imaging Hydrogen Peroxide in Living Cells

Yang Min ^a ,
Xia Lili ^b ,
Zhou Xiaoqin ^a ,
Jia Chengli ^a ,
Ji Min ^a,, ,
Wang Peng ^b,,

a.
School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210009
b.
Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009

Corresponding author: Ji Min, 101010516@seu.edu.cn Wang Peng, wangpeng@cpu.edu.cn
Received Date: 23 February 2020
Revised Date: 18 May 2020
Available Online: 19 June 2020
Fund Project: the General Program of National Natural Science Foundation of China 81671745Project supported by the General Program of National Natural Science Foundation of China (No. 81671745)

Figures(6)

Hydrogen peroxide (H₂O₂) plays an important role in various physiological and pathological processes in the form of molecular signals. Thus, it is of great significance to detect hydrogen peroxide in living cells or organisms quickly, efficiently and sensitively. In this study, a novel ratiometric fluorescent probe was designed to show the ratiometric fluorescence response to hydrogen peroxide. The probe showed the advantages of good selectivity, high sensitivity, low cytotoxicity and fast reaction rate in hydrogen peroxide detection. The probe also provided excellent performance in detecting both exogenous and endogenous hydrogen peroxide in living cells.
- ratiometric fluorescent probe,
- exogenous,
- endogenous,
- hydrogen peroxide,
- living cell imaging
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