Citation: Niu Wei, Xiao Dan, Cheng Hang, Xu Liang. Synthesis of 6α- and 6β-Hydroxydeoxycholic Acid[J]. Chinese Journal of Organic Chemistry, ;2020, 40(7): 2114-2119. doi: 10.6023/cjoc202002008 shu

Synthesis of 6α- and 6β-Hydroxydeoxycholic Acid

Key Laboratory of Drug Targeting, Ministry of Education, Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041

Corresponding author: Xu Liang, liangxu@scu.edu.cn
Received Date: 7 February 2020
Revised Date: 21 April 2020
Available Online: 11 May 2020
Fund Project: the National Natural Science Foundation of China 21871190Project supported by the National Natural Science Foundation of China (No. 21871190)

Figures(2)

6α- and 6β-hydroxydeoxycholic acids[DCA-6α-ol (6) and DCA-6β-ol (7)] are recently identified important tertiary bile acids derived from deoxycholic acid (3) in human liver. A rapid and robust synthesis of DCA-6α-ol (6) and DCA-6β-ol (7) from cholic acid (1) in 10 steps involing the key Mukaiyama aldol condensation, ozone oxidative cleavage and SmI₂ promoted reductive deoxygenation was conducted.
- bile acid,
- 6α-hydroxydeoxycholic acid,
- 6β-hydroxydeoxycholic acid,
- synthesis
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