Citation: Dong Wei, Wang Xin, Ge Zemei, He Fang, Li Runtao. Efficient Synthesis of Wogonin[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1725-1730. doi: 10.6023/cjoc202001033 shu

Efficient Synthesis of Wogonin

Dong Wei ^a ,
Wang Xin ^a ,
Ge Zemei ^a ,
He Fang ^b ,
Li Runtao ^a,,

a.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191
b.
Beijing Supertrack Pharma-Tech Co., LTD, Beijing 100029

Corresponding author: Li Runtao, lirt@bjmu.edu.cn
Received Date: 29 January 2020
Revised Date: 17 March 2020
Available Online: 10 April 2020
Fund Project: the National Natural Science Foundation of China 81673287Project supported by the National Natural Science Foundation of China (No. 81673287)

Figures(3)

Wogonin is an important flavonoid with a wide range of pharmacological activities, and its research has received increasing attention. The large amount of wogonin is the basis of in-depth research on it, but currently there are problems, such as difficulty in extracting from natural products, difficult to obtain fully synthetic raw materials, harsh reaction conditions, use of valuable and toxic reagents, difficulty in isolation and purification, or low yields. Herein, an efficient synthesis of wogonin from benzene-1, 3, 5-triol as starting material via seven steps with total yield of 58% was reported. This method possesses advantages including available starting materials, mild reaction conditions, simple operation and no column chromatography purification, which will provide a foundation for the large-scale preparation and in-depth study of wogonin.
- wogonin,
- benzene-1, 3, 5-triol,
- chrysin,
- total synthesis
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