Citation: Liang Kai, Zhou Qian, Xun Xiao, Ni Yadan, Li Jinfeng, Shi Yujun, Zhou Huanyu, Wu Xinxing, Shi Jian, Gao Lei, Dai Hong. Synthesis and Insecticidal Activities of Novel Pyrazole Amide Derivatives Containing a Thiazole Unit[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1665-1672. doi: 10.6023/cjoc202001029 shu

Synthesis and Insecticidal Activities of Novel Pyrazole Amide Derivatives Containing a Thiazole Unit

Liang Kai ^a,† ,
Zhou Qian ^a,† ,
Xun Xiao ^a ,
Ni Yadan ^a ,
Li Jinfeng ^a ,
Shi Yujun ^a,, ,
Zhou Huanyu ^a ,
Wu Xinxing ^a,, ,
Shi Jian ^b ,
Gao Lei ^a ,
Dai Hong ^a,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangshu 226019
b.
Analysis and Testing Center, Nantong University, Nantong, Jiangshu 226019

Corresponding author: Shi Yujun, yjshi2015@163.com Wu Xinxing, wuxinxng@163.com Dai Hong, daihong_2015@aliyun.com

^†

Received Date: 22 January 2020
Revised Date: 25 February 2020
Available Online: 29 February 2020
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21372135), the Science and Technology Project Fund of Nantong City (No. MS12019060) and the Program of High-level Talents of Nantong University (No. 03083031)the Science and Technology Project Fund of Nantong City MS12019060the National Natural Science Foundation of China 21372135the Program of High-level Talents of Nantong University 03083031

Figures(3)

In search of novel pyrazole amide compounds possessing good biological activities, a series of pyrazole amides were synthesized by introducing thiazole unit into pyrazole ring via amido bond, based on the lead of tebufenpyrad. The title compounds were structurually confirmed by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay displayed that all the title compounds exhibited 100% insecticidal activities against Oriental armyworm at 500 μg/mL. At the concentration of 500 μg/mL, seven compounds showed 70%~100% mortality rate against Aphis medicaginis. In addition, three compounds had 40%~50% insecticidal activity against Tetranychus cinnabarinus at 500 μg/mL.
- thiazole,
- pyrazole amide,
- synthesis,
- insecticidal activity
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