Citation: Zhang Min, Zheng Dandan, Ni Yadan, Liang Kai, Xun Xiao, Hu Lanping, Chen Qingwen, Yang Bing, Liang Zhipeng, Ding Ying, Shi Jian, Dai Hong. Synthesis and Bioactivities of Novel Pyrazole Amides Carrying Oxazole Moiety[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1772-1778. doi: 10.6023/cjoc202001028 shu

Synthesis and Bioactivities of Novel Pyrazole Amides Carrying Oxazole Moiety

Zhang Min ^a,† ,
Zheng Dandan ^a,† ,
Ni Yadan ^a ,
Liang Kai ^a ,
Xun Xiao ^a ,
Hu Lanping ^a,, ,
Chen Qingwen ^a ,
Yang Bing ^a,, ,
Liang Zhipeng ^b ,
Ding Ying ^a ,
Shi Jian ^b ,
Dai Hong ^a,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangshu 226019
b.
Analysis and Testing Center, Nantong University, Nantong, Jiangshu 226019

Corresponding author: Hu Lanping, hlp@ntu.edu.cn Yang Bing, yangbing111@ntu.edu.cn Dai Hong, daihong_2015@aliyun.com
Received Date: 20 January 2020
Revised Date: 27 February 2020
Available Online: 6 March 2020
Fund Project: the National Natural Science Foundation of China 21372135the Science and Technology Project Fund of Nantong City MS12019060Project supported by the National Natural Science Foundation of China (No. 21372135) and the Science and Technology Project Fund of Nantong City (No. MS12019060)

Figures(3)

In order to find new pyrazole amides with wonderful bioactivities, a series of novel pyrazole amide derivatives were synthesized by introducing substituted oxazole ring into the C-5 position of pyrazole skeleton based on the lead chlorantraniliprole. The aimed compounds were structurally characterized through ¹H NMR, ¹³C NMR and elemental analysis. The preliminary bioassay results exhibited that all the title compounds displayed more than 90% insecticidal activities against Mythimna separata (Walker) at 500 μg/mL. At the dosage of 100 μg/mL, five compounds possessed 90%~100% insecticidal activities against Mythimna separata (Walker), and three compounds exhibited insecticidal property against Aphis craccivora with 90%~100%. Additionally, at the dosage of 500 μg/mL, two compounds possessed insecticidal activity against Tetranychus cinnabarinus with 80%~100%.
- oxazole,
- pyrazole amide,
- synthesis,
- bioactivity
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