Citation: Abdukader Ablimit, Wang Rong, Mamat Marhaba, Liu Chenjiang. FeCl₂-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle[J]. Chinese Journal of Organic Chemistry, ;2020, 40(6): 1697-1703. doi: 10.6023/cjoc201912041 shu

FeCl₂-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

College of Chemical and Chemical Engineering, Xinjiang University, Urumqi 830046

Corresponding author: Abdukader Ablimit, ablimit1970@126.com Liu Chenjiang, pxylcj@126.com
Received Date: 18 December 2019
Revised Date: 5 February 2020
Available Online: 23 February 2020
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21562039)the National Natural Science Foundation of China 21562039

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A simple, practical and highly efficient synthesis of multi substituted isoxazole derivatives via cheap metal salt FeCl₂-catalyzed direct aerobic oxidative has been developed. Nineteen novel multi-substituted 3, 5-diaryl isoxazole derivtaves were synthesized and a single crystal was successfully cultivated. The products were get with about 70%~90% yields under mild conditions. The structures of products were fully characterized by ¹H NMR, ¹³C NMR, elemental analysis and X-ray crystal.
- iron catalysis,
- oxygen oxidation,
- isoxazole,
- heterocycle,
- N-O bond formation
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FeCl2-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

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通讯作者: 陈斌, bchen63@163.com

FeCl₂-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle