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Cytotoxic Secondary Metabolites from a Sea-Derived Fungal Strain of Hypoxylon rubiginosum FS521
- Corresponding author: Liu Hongxin, liuhx@gdim.cn Zhang Weimin, wmzhang@gdim.cn
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Citation:
Zhang Jie, Chen Yuchan, Liu Zhaoming, Guo Bohong, Gao Xiaoxia, Liu Hongxin, Zhang Weimin. Cytotoxic Secondary Metabolites from a Sea-Derived Fungal Strain of Hypoxylon rubiginosum FS521[J]. Chinese Journal of Organic Chemistry,
;2020, 40(5): 1367-1371.
doi:
10.6023/cjoc201912012
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One new compound, named hypoxone A (1), together with two new natural products 4, 8-dimethoxy-1-naphthol (2) and 1'-hydroxy-4', 8, 8'-trimethoxy[2, 2']binaphthalenyl-1, 4-dione (3), and fourteen known derivatives 4~17 were isolated from the broth extract of the marine fungus Hypoxylon rubiginosum FS521, which was isolated from a deep-sea sediment sample. Their structures were elucidated by interpretation of spectroscopic analysis and comparison with previously published data for the known ones. Moreover, compounds 1~4 were evaluated for their in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines, and compound 3 exhibited potent cytotoxic activity with IC50 values of 1.85, 3.21, 2.53, and 5.09 mmol·L-1, respectively.
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Keywords:
- marine fungus,
- Hypoxylon rubiginosum,
- cytotoxicity,
- polyketides
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