Citation: Xie Tao, He Haibing, Gao Shuanhu. Synthetic Progress of Polycyclic Xanthone[J]. Chinese Journal of Organic Chemistry, ;2020, 40(3): 551-562. doi: 10.6023/cjoc201911007 shu

Synthetic Progress of Polycyclic Xanthone

Xie Tao ^a ,
He Haibing ^b,, ,
Gao Shuanhu ^a,b,,

a.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062
b.
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062

Corresponding author: He Haibing, hbhe@chem.ecnu.edu.cn Gao Shuanhu, shgao@chem.ecnu.edu.cn
Received Date: 6 November 2019
Revised Date: 26 November 2019
Available Online: 11 December 2019
Fund Project: Program of Shanghai Academic/Technology Research Leader 18XD1401500Program of Shanghai Science and Technology Committee 18JC1411303Project supported by the National Natural Science Foundation of China (Nos.21971068, 21772044), the Program of Shanghai Academic/Technology Research Leader (No.18XD1401500), the Program of Shanghai Science and Technology Committee (No.18JC1411303), the National Young Top-Notch Talent Support Program and the Fundamental Research Funds for the Central UniversitiesProject supported by the National Natural Science Foundation of China 21971068Project supported by the National Natural Science Foundation of China 21772044

Figures(13)

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated angular hexacyclic frameworks. In the last decade, there has been a noticeable increase in reports on both synthetic and pharmacological investigations of this class of natural molecules due to their unique chemical structures and biological activities. Most members of this class of molecules show strong activities towards Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, potent antifungal activity and antitumour activity. The synthetic studies of some members of this class of natural products is summarized.
- polycyclic xanthone,
- natural product,
- total synthesis
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