Citation: Yan Lijun, Yan Yuxin, Chen Xuebing, Wang Yongchao. Advances in Multicomponent Asymmetric Cascade Synthesis Involving Hydrogen-Bond-Activated Nitroolefins[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 856-872. doi: 10.6023/cjoc201910039 shu

Advances in Multicomponent Asymmetric Cascade Synthesis Involving Hydrogen-Bond-Activated Nitroolefins

a.
College of Vocational and Technical Education, Yunnan Normal University, Kunming 650092
b.
School of Science, Honghe University, Mengzi, Yunnan 6611992

Corresponding author: Chen Xuebing, orangekaka@126.com Wang Yongchao, yongchaowang126@126.com
Received Date: 31 October 2019
Revised Date: 2 December 2019
Available Online: 19 December 2019
Fund Project: the Applied Basic Research Project Foundation of Yunnan Provincial Department of Science and Technology 2017FD156Project supported by the Applied Basic Research Project Foundation of Yunnan Provincial Department of Science and Technology (Nos. 2018FD016, 2017FD073, 2017FD156)the Applied Basic Research Project Foundation of Yunnan Provincial Department of Science and Technology 2018FD016the Applied Basic Research Project Foundation of Yunnan Provincial Department of Science and Technology 2017FD073

Figures(16)

Organocatalytic multicomponent asymmetric cascade reaction is generally regarded as one of the most effective methods for constructing complex chiral compounds. Bifunctional chiral catalysts are an important class of single-molecule double-activated organic catalysts, which can simultaneously activate hydrogen bonds of multiple reactive substrates to achieve the formation of multiple new bonds and stereoselective control of multiple chiral centers. Nitroolefins are important organic reaction synthons, which can participate in a variety of asymmetric cascade reactions by hydrogen bond activation. In this paper, the recent advances in nitroolefins-involved multicomponent asymmetric cascade reactions catalyzed by bifunctional organocatalysts involving chiral bifunctional thiourea amines, squaramide amines and other bifunctional catalysts are reviewed. Specifically, the catalytic systems, characteristics, mechanisms are systematically expounded, and the application of this research field is also prospected.
- bifunctional catalysts,
- hydrogen-bond activation,
- nitroolefin,
- multicomponent reactions,
- asymmetric synthesis,
- cascade reaction
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沈阳化工大学材料科学与工程学院沈阳 110142