Citation: Gu Guoxian, Hu Yang, Liu Shaodong, Dong Xiu-Qin, Zhang Xumu. Indan-f-amphox: An Efficient PNN Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of β-Aryl β-Ketoesters[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 997-1002. doi: 10.6023/cjoc201910032 shu

Indan-f-amphox: An Efficient PNN Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of β-Aryl β-Ketoesters

Gu Guoxian ^a ,
Hu Yang ^b ,
Liu Shaodong ^c ,
Dong Xiu-Qin ^b,, ,
Zhang Xumu ^d,,

a.
School of Chemical Engineering and Technology, Tianjin Key Laboratory of Chemical Process Safety, Hebei University of Technology, Tianjin 300130, China
b.
College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China
c.
Department of Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA
d.
Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China

Corresponding author: Dong Xiu-Qin, zhangxm@sustc.edu.cn Zhang Xumu, xiuqindong@whu.edu.cn
Received Date: 28 October 2019
Revised Date: 28 November 2019
Available Online: 11 December 2019
Fund Project: Project supported by the Shenzhen Free Exploration Fund (No. JCYJ20170817104853520)the Shenzhen Free Exploration Fund JCYJ20170817104853520

Figures(2)

A new chiral tridentate PNN ligand, indan-f-amphox (a sister ligand of f-amphox), was synthesized and applied in iridium-catalyzed asymmetric hydrogenation of β-aryl β-ketoesters. A wide range of β-aryl β-ketoesters are reduced using an Ir(Ⅲ)-indan-f-amphox catalyst with excellent enantioselectivities and reactivities (up to 99% ee, TON=10000).
- PNN ligand,
- asymmetric hydrogenation,
- β-ketoesters,
- f-amphox
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