Citation: Ren Xinfeng, Song Xiaoping, Ma Yingchao, Li Ya. Method for the Synthesis of 1, 1-Dichloroalkenes[J]. Chinese Journal of Organic Chemistry, ;2020, 40(5): 1388-1393. doi: 10.6023/cjoc201910030 shu

Method for the Synthesis of 1, 1-Dichloroalkenes

Ren Xinfeng ^b,, ,
Song Xiaoping ^a ,
Ma Yingchao ^b ,
Li Ya ^b,,

a.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 570100
b.
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620

Corresponding author: Ren Xinfeng, renxf@sues.edu.cn Li Ya, ya.li@sues.edu.cn
Received Date: 25 October 2019
Revised Date: 8 December 2019
Available Online: 3 January 2020
Fund Project: Project supported by the Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University (No.2013-6)Project supported by the Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University 2013-6

Figures(4)

The 1, 1-dichloroalkene structural unit is found in many natural products. 1, 1-Dichloroalkenes are important intermediates, which have been widely used in the synthesis of alkynes, halogenated acetylenes and aromatic compounds. In this paper, a new dichloroolefinating reagent, dichloromethyl 2-pyridyl sulfone, was reported. 1, 1-Dichloroalkenes can be conveniently obtained from the reaction of dichloromethyl 2-pyridyl sulfone with aromatic aldehydes using t-BuOK as base. This method has the advantage of operational simplicity, usage of easily available reagents and easy purification, which may find applications in organic synthesis.
- dichloromethyl sulfone,
- 1, 1-dichloroalkenes,
- aromatic aldehydes
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