Citation: Bao Kun, Wei Jun, Sheng Rong. Synthesis of α, α, γ, γ-Tetrafluoro-β-hydroxy Ketones and α-Fluoroacetophenones via 1, 3-Diaryl-1, 3-diketones[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 930-937. doi: 10.6023/cjoc201910014 shu

Synthesis of α, α, γ, γ-Tetrafluoro-β-hydroxy Ketones and α-Fluoroacetophenones via 1, 3-Diaryl-1, 3-diketones

Bao Kun ^a,b ,
Wei Jun ^b ,
Sheng Rong ^b,,

a.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014
b.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058

Corresponding author: Sheng Rong, shengr@zju.edu.cn
Received Date: 11 October 2019
Revised Date: 7 December 2019
Available Online: 27 December 2019

Figures(6)

α, α, γ, γ-Tetrafluoro-β-hydroxy ketones and α-fluoroacetophenones are widely used in the fields of organic chemistry, agrochemicals, and pharmaceuticals. A mild and excellent method to synthesize α, α, γ, γ-tetrafluoro-β-hydroxy ketones and α-fluoroacetophenones via various 1, 3-diaryl-1, 3-diketones has been developed. With the modification of reaction conditions, two different products could be obtained in moderate to good yields, respectively.
- α, α, γ, γ-tetrafluoro-β-hydroxy ketones,
- α-fluoroacetophenones,
- 1, 3-diaryl-1, 3-diketones
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