Citation: Wu Bowen, Cui Xinxin, Zhu Ting, Wang Shenghui, Lu Chaofan, Wang Jinjie, Dang Hexiang, Zhang Saiyang, Ding Li'na, Jin Chengyun. Design, Synthesis and Anticancer Activity Studies of Novel Trimethoxyphenyl-quinoline Derivatives[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 978-987. doi: 10.6023/cjoc201909016 shu

Design, Synthesis and Anticancer Activity Studies of Novel Trimethoxyphenyl-quinoline Derivatives

Wu Bowen ^a,c,† ,
Cui Xinxin ^a,c,† ,
Zhu Ting ^a,c ,
Wang Shenghui ^b ,
Lu Chaofan ^b ,
Wang Jinjie ^a,c ,
Dang Hexiang ^a,c ,
Zhang Saiyang ^a,b,d,, ,
Ding Li'na ^a,c,, ,
Jin Chengyun ^a,c,,

a.
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou 450001
b.
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001
c.
Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou 450001
d.
Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001

Corresponding author: Zhang Saiyang, saiyangz@zzu.edu.cn Ding Li'na, dinglina123@126.com Jin Chengyun, cyjin@zzu.edu.cn

^†

Received Date: 10 September 2019
Revised Date: 21 November 2019
Available Online: 11 December 2019
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 81703541, 81673322) and the China Postdoctoral Science Foundation (No. 2018M632812)the National Natural Science Foundation of China 81673322the National Natural Science Foundation of China 81703541the China Postdoctoral Science Foundation 2018M632812

Figures(9)

With the expectation to find out novel and effective anti-tumor agents, a series of novel trimethoxyphenyl-quinoline hybrids were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines (EC-109, human esophageal cancer cells; PC-3, human prostate cancer cells; MGC-803, human gastric cancer cells). N-(3-(Chloromethyl)benzyl)-3, 4, 5-trimethoxy-N-(quinolin-8-yl)benzamide (12j) showed the most potent antitumor activity against PC-3 cells with IC₅₀ value of 9.23 μmol/L. Meanwhile, compound 12j inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound 12j could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway.
- quinoline,
- trimethoxyphenyl,
- anticancer,
- cell cycle arrest,
- apoptosis
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