Citation: Guo Yuanyuan, Liu Zhenwei, Zhu Mingxiang, Li Linlin, Li Jingya, Zou Dapeng, Wu Yusheng, Wu Yangjie. Copper-Promoted Dimethylthiolation of Benzamides under Assistance of 8-Aminoquinoline Group[J]. Chinese Journal of Organic Chemistry, ;2020, 40(3): 724-730. doi: 10.6023/cjoc201908036 shu

Copper-Promoted Dimethylthiolation of Benzamides under Assistance of 8-Aminoquinoline Group

Guo Yuanyuan ^a ,
Liu Zhenwei ^a ,
Zhu Mingxiang ^a ,
Li Linlin ^a ,
Li Jingya ^b ,
Zou Dapeng ^a,, ,
Wu Yusheng ^b,, ,
Wu Yangjie ^a,,

a.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052
b.
Tetranov Biopharm, LLC, Zhengzhou 450052

Corresponding author: Zou Dapeng, zdp@zzu.edu.cn Wu Yusheng, yusheng.wu@tetranovglobal.com Wu Yangjie, wyj@zzu.edu.cn
Received Date: 27 August 2019
Revised Date: 5 November 2019
Available Online: 21 November 2019
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21172200, 21702191)the National Natural Science Foundation of China 21702191the National Natural Science Foundation of China 21172200

Figures(2)

Cu(Ⅱ)-promoted dimethylthiolation of C(sp²)-H bonds using DMSO as the methylthiolation source with the assistance of an 8-aminoquinoline directing group have been developed. A number of dimethylthiolated benzamides were efficiently synthesized using CuSO₄·5H₂O as a promoter in moderate to good yields. In addition, this reaction system features facile conditions and no other oxidant additive was required.
- Dimethylthiolation,
- DMSO,
- 8-Aminoquinoline,
- Copper-promoted
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