Citation: Zhao Fang, Hu Yang, Li Qiao, Hu Shengli. I₂/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 1068-1073. doi: 10.6023/cjoc201908031 shu

I₂/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea

College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002

Corresponding author: Hu Shengli, hushengli168@126.com
Received Date: 23 August 2019
Revised Date: 19 October 2019
Available Online: 7 November 2019
Fund Project: the Foundation of Hubei Provincal Ministry of Education D20112507the Science Technology Foundation for Creative Research Group of Hubei Department of Education T201311Project supported by the Science Technology Foundation for Creative Research Group of Hubei Department of Education (No. T201311) and the Foundation of Hubei Provincal Ministry of Education (No. D20112507)

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Coumarin and thiazole are two classes of important heterocycles with many biological activities and pharmacological effects. It is very meaningful to synthesize thiazolyl coumarin derivatives in medicinal chemistry area. In this study, a facile and efficient one-pot process was developed to synthesize substituted aminothiazoles from 3-acetylcoumarins and thiourea/N-substituted thioureas under the media of I₂/CuO. All target molecules were characterized by NMR, IR spectra and MS.
- coumarin,
- 2-aminothiazole,
- one-pot reaction,
- I₂/CuO
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

I2/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea

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通讯作者: 陈斌, bchen63@163.com

I₂/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea