Citation: Cao Xueli, Guo Xiao. A New Method for the Synthesis of 1, 3, 4-Thiadiazine Derivatives[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 1050-1054. doi: 10.6023/cjoc201908005 shu

A New Method for the Synthesis of 1, 3, 4-Thiadiazine Derivatives

Cao Xueli ^a ,
Guo Xiao ^b,,

a.
College of Chemistry and Chemical Engineering, Taishan University, Taian, Shandong 271000
b.
Jewim Pharmaceutical(Shandong) Co., Ltd, Taian, Shandong 271000

Corresponding author: Guo Xiao, guoxiao@zju.edu.cn
Received Date: 3 August 2019
Revised Date: 24 October 2019
Available Online: 2 December 2019
Fund Project: the Research Foundation for Talented Scholars of Taishan University 5002353Project supported by the Research Foundation for Talented Scholars of Taishan University (No. 5002353)

Figures(2)

An efficient method for the preparation of 1, 3, 4-thiadiazine derivatives has been reported. With 2, 5-dihydroxy-1, 4-dithiane and α-chloroindole containing different substituents, 13 compounds were synthesized. The yields of the compounds were above 82% except (E)-4-phenyl-2-styryl-5, 6-dihydro-4H-1, 3, 4-thiadiazin-5-ol (3m). Furthermore, the proposed reaction mechanism was discussed. The developed method features simple operation, mild reaction condition, environmentally friendly, high yield and a broad range of substrate applicability. It provides a new way for the synthesis of 1, 3, 4-thiadiazine derivatives.
- α-chloroindole,
- 1, 3, 4-thiadiazine,
- synthesis
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