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Citation: Chen Shushuai, Liu Hongxin, Liu Zhaoming, Li Saini, Chen Yuchan, Li Haohua, Li Dongli, Zhang Weimin. Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis[J]. Chinese Journal of Organic Chemistry, ;2020, 40(1): 209-214. doi: 10.6023/cjoc201907041 shu

Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis

  • a.

    School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020

  • b.

    State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070

  • Corresponding author: Li Dongli, wyuchemldl@wyu.edu.cn Zhang Weimin, wmzhang@gdim.cn
  • Received Date: 26 July 2019
    Revised Date: 10 September 2019
    Available Online: 25 January 2019

    Fund Project: the National Natural Science Foundation of China 31600271the Guangdong Provincial Project for Science and Technology 2107A020211023the Pearl River Science and Technology New Star Fund of Guangzhou City 201806010080Project supported by the National Natural Science Foundation of China (No. 31600271), the Guangdong Provincial Project for Science and Technology (No. 2107A020211023), and the Pearl River Science and Technology New Star Fund of Guangzhou City (No. 201806010080)

Figures(4)

  • Six polyketides were isolated from the fermentation broth of an endophytic fungus Trichoderma spirale A725 of the medicinal plant Morinda officinalis by silica gel, reversed phase silica column chromatography, sephadex LH-20 and high performance preparative liquid chromatography. Their structures were elucidated to be 6-hydroxy-4-isopropyl-1, 8-dimethyl-spiro[4.5]deca-1, 8-dien-7-one (1), 2-hydroxy-2, 5-dimethyl-7-oxo-5, 7-dihydro-2H-furo[3, 4-b]pyran-4-carboxylicacid (2), 3-ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (3), harzialactone A (4), 3-hydroxy-5-(4-hydroxybenzyl)dihydrofuran-2(3H)-one (5), and 4-acetyl-3-hydroxy-6-methyl-pyran-2-one (6) on the basis of extensive spectral analysis. Among them, compounds 1 and 2 were new compounds, and compound 3 was a new natural product. Moreover, the cytotoxicities of compounds 1~6 were evaluated against four cancer cell lines (Hep G-2, MCF-7, SF-268 and A549). However, none of them exhibited cytotoxic activity against the tested tumor cells.
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  • 1. 

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