Citation: Pi Chao, Qu Yaping, Cui Xiuling, Wu Yangjie. Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides[J]. Chinese Journal of Organic Chemistry, ;2020, 40(3): 740-747. doi: 10.6023/cjoc201907040 shu

Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides

Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, College of Chemistry, Zhengzhou University, Zhengzhou 450052

Corresponding author: Cui Xiuling, cuixl@zzu.edu.cn Wu Yangjie, wyj@zzu.edu.cn
Received Date: 26 July 2019
Revised Date: 23 October 2019
Available Online: 1 November 2019
Fund Project: the Key International Cooperation Projects from Chinese Ministry of Science and Technology 2016YFE0132600Project supported by the Key International Cooperation Projects from Chinese Ministry of Science and Technology (No. 2016YFE0132600)

Figures(4)

A highly efficient and regioselective C-3-alkylation of 2-arylindoles with maleimides has been developed using Ag(I) as catalyst. 3-(2-Aryl-1H-indol-3-yl)pyrrolidine-2, 5-diones were afforded with high yields (up to 97%) under relatively mild reaction conditions. The method features operational simplicity and avoiding external oxidant.
- silver-catalyzed,
- 2-arylindoles,
- maleimides,
- alkylation
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