Citation: Xu Wenzhi, Li Xue, Han Mengnan, Zhou Tingting, Yang Yutao, Li Wei. A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging[J]. Chinese Journal of Organic Chemistry, ;2020, 40(1): 181-185. doi: 10.6023/cjoc201907039 shu

A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002

Corresponding author: Xu Wenzhi, wzxu2008@sinano.ac.cn Li Wei, liweihebeilab@163.com
Received Date: 26 July 2019
Revised Date: 28 August 2019
Available Online: 25 January 2019
Fund Project: the National Natural Science Foundation of China 21807021Project supported by the National Natural Science Foundation of China (Nos. 21702043, 21807021)the National Natural Science Foundation of China 21702043

Figures(5)

Hydrazine is an important raw material and catalyst in chemical industry. However, hydrazine is very harmful to human organs. A new type of probe was developed based on the synergistic effect. Two recognition sites were introduced into the probe to improve performance to hydrazine, which has good specificity to hydrazine. The limit of detection (LOD) for N₂H₄ was 0.05~10.0 μmol·L^-1. Moreover, the probe could detect N₂H₄ in BT-474 cells.
- hydrazine,
- synergistic effect,
- cell imaging,
- fluorescent probe
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