Citation: Wu Yan, Wang Shan, Zhang Hailing, Chen Rui, He Shuhua. Cesium-Catalyzed N-Carboxamidation of Indoles for Synthesis of Indole-1-carboxamides[J]. Chinese Journal of Organic Chemistry, ;2019, 39(12): 3567-3573. doi: 10.6023/cjoc201906012 shu

Cesium-Catalyzed N-Carboxamidation of Indoles for Synthesis of Indole-1-carboxamides

Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Sichuan 408000

Corresponding author: He Shuhua, thshuhua@163.com
Received Date: 12 June 2019
Revised Date: 24 July 2019
Available Online: 7 December 2019
Fund Project: the Youth Talent Growth Plan Project of Yangtze Normal University 2018QNRC11Project supported by the Basic and Frontier Research Project of Chongqing City (No. Cstc2018jcyjAX0721), the Youth Talent Growth Plan Project of Yangtze Normal University (No. 2018QNRC11), and the Education Commission of Chongqing City (No. KJQN201801404)the Basic and Frontier Research Project of Chongqing City Cstc2018jcyjAX0721the Education Commission of Chongqing City KJQN201801404

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A protocol for the synthesis of a series of indole-1-carboxamides was reported via the N-arboxamidation of indole derivatives with aryl (alkyl) isocyanates catalyzed by 5.0 mol% cesium hydroxide monohydrate (CsOH·H₂O). This method is suitable for different indole derivatives and aryl (alkyl) isocyanates, for giving corresponding products in excellent yields. Compared to the reported methods, this protocol has the advantages of mild reaction conditions, wild functional group tolerance, simple operation and excellent yields. An efficient route to indole-1-carboxamides is previded.
- cesium-catalyzed N-arboxamidation,
- indole-1-carboxamides,
- indole derivatives,
- aryl (alkyl) isocyanates
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