Citation: Huang Guozhi, Ren Jie, Zheng Xiaoxiao, Wu Fanhong, Wu Jingjing. A Convenient Synthesis of β, β-Difluoro-β-iodo-1-phenylethan-1-ols[J]. Chinese Journal of Organic Chemistry, ;2019, 39(12): 3475-3482. doi: 10.6023/cjoc201905051 shu

A Convenient Synthesis of β, β-Difluoro-β-iodo-1-phenylethan-1-ols

School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418

Corresponding author: Wu Fanhong, wfh@sit.edu.cn Wu Jingjing, wjj_693@163.com
Received Date: 30 May 2019
Revised Date: 28 July 2019
Available Online: 7 December 2019
Fund Project: Project supported by the General Project of the National Natural Science Foundation of China (No. 21672151)the General Project of the National Natural Science Foundation of China 21672151

Figures(5)

The synthesis of α, α, α-iodo-difluoromethyl alcohols via the high selective reduction of iododifluoromethyl ketones by NaBH₄ in methanol at 0℃ was reported. The reaction has some advantages, such as mild condition, simple synthetic route, and high yield. A convenient way to synthesize more difluoromethylation agents was provided.
- iodo-difluoromethyl ketones,
- NaBH₄,
- iodo-difluoromethyl alcohol,
- selective reduction
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