Citation: Chen Guoqing, Xie Zongbo, Liu Yishuai, Meng Jia, Le Zhanggao. Synthesis of 2, 4-Disubstituted Quinolines in Deep Eutectic Solvents[J]. Chinese Journal of Organic Chemistry, ;2020, 40(1): 156-161. doi: 10.6023/cjoc201905040 shu

Synthesis of 2, 4-Disubstituted Quinolines in Deep Eutectic Solvents

Chen Guoqing ^a,b ,
Xie Zongbo ^a,b,, ,
Liu Yishuai ^b ,
Meng Jia ^b ,
Le Zhanggao ^a,b,,

a.
State Key Laboratory of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013
b.
Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Corresponding author: Xie Zongbo, zbxie@ecut.edu.cn Le Zhanggao, zhgle@ecut.edu.cn
Received Date: 19 May 2019
Revised Date: 20 July 2019
Available Online: 5 January 2019
Fund Project: the National Natural Science Foundation of China 20161BCB24006the National Natural Science Foundation of China 21462001Project supported by the National Natural Science Foundation of China (Nos. 21462001, 11765002), and the Science and Technology Projects of Jiangxi Province (Nos. 20161BCB24006, 20181BAB203019)the National Natural Science Foundation of China 11765002the National Natural Science Foundation of China 20181BAB203019

Figures(3)

In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2, 4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1:2, the yield up to 98% was achieved at 80℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates.
- deep eutectic solvent,
- choline chloride,
- zinc chloride,
- cyclization coupling,
- 2, 4-disubstituted quinoline
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