Citation: Li Sha, Xu Jiayu, Luo Xian, Yang Wenhan, Yao Changsheng. Efficient N-Heterocyclic Carbene-Catalyzed Cascade Synthesis of Functionalized Naphthopyranone[J]. Chinese Journal of Organic Chemistry, ;2020, 40(2): 470-477. doi: 10.6023/cjoc201905034 shu

Efficient N-Heterocyclic Carbene-Catalyzed Cascade Synthesis of Functionalized Naphthopyranone

Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116

Corresponding author: Yao Changsheng, csyao@jsnu.edu.cn
Received Date: 14 May 2019
Revised Date: 19 September 2019
Available Online: 9 February 2019
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21871113, 21372101)Project supported by the National Natural Science Foundation of China Nos. 21871113Project supported by the National Natural Science Foundation of China 21372101

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An efficient N-heterocyclic carbene (NHC)-catalyzed "Michael-Michael-Lactonization" cascade process involving chalcone derivatives and α-bromoenals for the syntheses of functionalized naphthopyranones was disclosed. This approach was qualified with good yields, readily available starting materials and mild reaction conditions.
- N-heterocyclic carbene (NHC),
- α-bromoenals,
- chalcone derivatives,
- functionalized naphthopyranone,
- cascade reaction
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