Citation: Guo Jiaocen, Ma Qingyun, Kong Fangdong, Xie Qingyi, Zhou Liman, Ding Qiong, Wu Yougen, Zhao Youxing. Meroterpenoids from the Fruiting Bodies of Ganoderma ahmadii Steyaret and Their Protein Tyrosine Phosphatase 1B Inhibitory Activities[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3264-3268. doi: 10.6023/cjoc201905010 shu

Meroterpenoids from the Fruiting Bodies of Ganoderma ahmadii Steyaret and Their Protein Tyrosine Phosphatase 1B Inhibitory Activities

Guo Jiaocen ^a,b ,
Ma Qingyun ^b ,
Kong Fangdong ^b ,
Xie Qingyi ^b ,
Zhou Liman ^b ,
Ding Qiong ^a ,
Wu Yougen ^a,, ,
Zhao Youxing ^b,,

a.
College of Horticulture, Hainan University, Haikou 570228
b.
Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101

Corresponding author: Wu Yougen, wygeng2003@163.com Zhao Youxing, zhaoyouxing@itbb.org.cn
Received Date: 7 May 2019
Revised Date: 14 June 2019
Available Online: 24 November 2019
Fund Project: the China Agriculture Research System CARS-21the Natural Science Foundation of Hainan Province 2019CXTD411the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences 1630052016008Project supported by the Natural Science Foundation of Hainan Province (Nos. 219MS078, 2019CXTD411), the China Agriculture Research System (No. CARS-21) and the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (Nos. 17CXTD-15, 1630052016008)the Natural Science Foundation of Hainan Province 219MS078the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences 17CXTD-15

Figures(2)

Three new meroterpenoids of ganoduriporols C~E were isolated from the fruiting bodies of Ganoderma ahmadii Steyaret by silica gel column, high performance liquid chromatography (HPLC) and other chromatography methods. Their structures were determined by spectroscopic techniques including NMR and HR-ESI-MS. Their inhibitory activities for protein tyrosine phosphatase 1B (PTP1B) in vitro were tested. The results showed that the three compounds had obvious PTP1B inhibitory activitiy with the IC₅₀ values of 19.1, 17.81, and 29.6 μmol·L^-1, respectively.
- Ganoderma ahmadii Steyaret,
- meroterpenoid compound,
- PTP1B inhibitory effect
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